I usually will follow back another developer or person of interest but beyond that I do nothing. I may send a "thank you to new followers" tweet or something like that but I don't do the DMs and all that other crap, like you said...it's annoying. Lately I've been getting follows from big accounts like Siri's voice actress and Nolan Bushnell. Didn't even send me an auto DM so I just said hello. Otherwise I just push forward and try to ignore the annoying crap. Most of the time you never hear from them again anyway.
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